Vaughan’s family had been settled at Bredwardine, Herefordshire for at least seven generations. His father, who inherited at least 18 manors in Brecon and Glamorgan, moved to Pembrey, Carmarthenshire, where Vaughan was born in about 1572.
With a Wiltshire estate, and probably the support of the 2nd earl of Pembroke, Vaughan was immediately appointed to the commission of the peace, and though a newcomer, was pricked sheriff two years later. Despite the proximity of Falstone to several parliamentary boroughs, he is not known to have sought election in 1604, nor is he likely to have merited consideration for a county seat. It is thus surprising that he should have been returned as knight of the shire in February 1606, at a by-election caused by the disallowance of Sir Thomas Thynne’s return.
Vaughan’s career outside Parliament is obscure. He subscribed £37 to the Virginia Company in 1610, but made no payment, despite legal processes against him, until 1620.
Vaughan died, intestate, on 7 May 1639. His son and heir, Sir Charles*, predeceased him without issue, and the estate went to his second son, Sir George, who served as royalist sheriff for Wiltshire in 1643, and was wounded at the battle of Lansdown.
