Littleton was descended from the eldest son of his namesake, the fifteenth-century jurist famed for his treatise on tenures.
Littleton was excluded from most local offices during the 1620s, and may have sought election as a means of affirming his status. He was returned for Worcestershire’s first seat in 1621, and was nominated to attend a conference with the Lords to prepare a petition on recusancy (21 February).
There is no evidence that Littleton was active in the 1626 Parliament, but a bill was introduced to settle a jointure on his wife, whose lands were sold in the 1620s. The bill received two readings and was committed, but proceeded no further. After Littleton’s mother died in 1630 he settled part of her jointure on his wife.
In 1639 Littleton purchased an estate at Westbury in Buckinghamshire. By 1640 his gross income totalled over £3,200 p.a.
