Jeffreys came of a leading Breconshire family. His father and his uncle, Sir Jeffrey Jeffreys, were wealthy tobacco merchants who sat for Brecon county and borough respectively. A gamester, and a popular member of White’s, he soon ran through his private fortune.
After unsuccessfully contesting Brecon borough on coming of age, Jeffreys was returned for the county by a small majority in 1734, representing it till 1747, when he was brought in on the government interest at Dartmouth. He began his career in opposition, attaching himself to Pulteney, who after Walpole’s fall made him joint secretary of the Treasury, worth about £5,000 p.a. in wartime, an appointment described by Horace Walpole as White’s contribution to the Government.
In 1746 Pelham told James West, his secretary as chancellor of the Exchequer, that ‘as Mr. Scrope was very old’ he desired West to replace Jeffreys; but that ‘he was so pressed by Mr. Jeffreys’ friends that he could not remove him without some provision’, and that West would have to allow him £1,000 p.a. till other arrangements could be made, meanwhile retaining the office of secretary to Pelham. When West became senior secretary on Scrope’s death in 1752, Jeffreys was quartered on the new joint secretary, Nicholas Hardinge.
