Wyse came from a substantial Devonshire family living near Tavistock which owned the manor of Greystone in Lezant, just over the border with Cornwall.
Early on in his career Wyse came into contact with various other members of the gentry of the West Country: in 1402, for instance, he stood surety for William Carew, esquire, and in 1412 he was party as a feoffee for William Wynard (afterwards recorder of Exeter) to a mortgage of £120 secured on the manor of Cobham Week. His interest in the affairs of both shires in which he owned land is suggested by his attendance on 23 Oct. 1414 at the shire elections for Devon (held at Exeter castle) and on 5 Nov. following at those for Cornwall (conducted at Lostwithiel).
On his return to England, Hugh Courtenay, earl of Devon, granted Wyse a lease for 50s. a year of his mills and other property at Okehampton. It seems quite likely, indeed, that there was a family connexion between the Wyses and the Courtenays, for after the earl’s death in 1422 our MP’s son, Thomas, was made feodary of the estates of the earldom during the minority of the heir, Earl Thomas.
When, in 1437, Thomas Mede, abbot of Tavistock, was required by Bishop Lacy of Exeter to defend himself in his court at Chudleigh on charges of wasting the assets of the abbey, it was alleged against him that he had leased out at farm to Wyse for the term of the latter’s life, and for as little as £36 a year, the abbey’s principal manor of Hurdwick and, furthermore, had promised to provide him with a bottle of wine for every night he should spend on the premises. In October that year Wyse, aged over 60 on his own testimony, provided proof that John, son of (Sir) John Colshull II had reached his majority, but he did not live much longer. In 1445 the bishop granted an indulgence to all who would pray for the souls of the three husbands of Constance Coffyn (of whom Wyse was the last), in the aisle dedicated to St. Thomas the Martyr, which she had newly built in Tavistock parish church.
