Nothing is known of Lopynford’s family or background, but the earliest references to him describe him as being ‘of Devon’. He owned a house at Honiton, where he resided towards the end of his life, and through his marriage he acquired over 200 acres of land elsewhere in the east of the county, along with a small estate at Dunster and Carampton in Somerset.
Lopynford is last recorded in February 1420, then acting as a surety that John Hankford and others would keep the terms of an Exchequer lease of lands in Somerset, and he died before 1429. His daughter and heir, Alice, married John Orchard, probably a member of the family seated at Orchard Wyndham.
