Gibbon met Guise at Lausanne in 1763, and found him ‘a very sensible well-bred man’.
Guise, with the support of the Berkeley interest, represented Gloucestershire without a contest. In Parliament he voted against North’s Administration; the Public Ledger in 1779 describes him as ‘a very independent man’. He voted for Shelburne’s peace preliminaries, 18 Feb. 1783. Guise is only twice reported to have spoken in the House: on militia affairs, 25 Apr. 1780, and in favour of sending a relief fund to Barbados, 24 Jan. 1781.
He died 6 Apr. 1783.
