Hampden was the second son of William Hampden, Member for East Looe in 1593. His birth almost certainly occurred while his mother Elizabeth, daughter of Sir Henry Cromwell, was visiting her aunt, Joan Warren, as he was baptized at Barking in Essex early in November 1596. Within five months, however, his father was dead leaving his mother, with the help of their relatives and friends, to deal with the problems arising from the settlement of William’s estate and the wardship of his elder brother, John.
Hampden was educated at Thame grammar school, where the emphasis was on the study of classical languages and divinity.
In 1625 Hampden, along with his brother, was returned to the Commons by the newly re-enfranchised Buckinghamshire borough of Wendover, but he played no recorded part in the Parliament’s proceedings. An attempt was also made to secure his return the following year, for in January 1626 his maternal uncle, Henry Cromwell*, sought the help of the Carnsew family to secure him a seat in Cornwall, either at Camelford or Tintagel (Bossiney). Hampden was recommended to Sir Richard Carnsew as ‘a noble esquire ... [who] would gladly serve his country in this next Parliament.’
His life thereafter is poorly documented. He does not seem to have married,
