Radcliffe began life as the younger son of a younger son of the 1st earl of Sussex, and only inherited the earldom because of his own longevity and the failure of the senior branch of the family. In 1553 his mother’s family assigned a Crown grant of the site (and 573 acres of the demesnes) of the dissolved nunnery of Elstow, just outside Bedford, to his father, Sir Humphrey, together with the rectories of Elstow, Willshampstead and Kempston. This estate, and his Court connections, apparently gave Sir Humphrey sufficient status to represent Bedfordshire five times during the 1550s.
Sir Humphrey’s death in 1566 deprived the family of much of their local influence, but Radcliffe’s brother-in-law Henry Cheke was returned for Bedford in 1571 and 1572, and his elder brother Thomas† was unsuccessfully nominated for one of the county seats in 1584 by his cousin the 4th earl of Sussex (Sir Henry Radcliffe†).
In addition to the Elstow estate, Radcliffe inherited on his mother’s death in 1594 a life interest in nearby Houghton Grange, a Crown lease of further property in Elstow and (possibly) an extent of lands worth £100 a year in Riseley, Bedfordshire. He was probably the grantee of a 50-year lease of the manor of Denny, Cambridgeshire in 1595, and in 1609 he and his relative Robert, 5th earl of Sussex briefly obtained a patent for concealed lands.
Radcliffe probably lived beyond his modest means, either at Court, where his sister Mary served as chief lady of the Privy Chamber to Queen Elizabeth,
Radcliffe was the reversionary heir to most of his family’s extensive estates in Essex and Norfolk, an inheritance which must have seemed a remote prospect until 1619-20, when the sons of Robert, 5th earl of Sussex died in quick succession.
Radcliffe’s second wife died in 1633, whereupon he quickly married another widow. By 1640 the couple were living at Gorhambury, Hertfordshire, which they presumably leased from Sir Thomas Meautys*, whose cousin Frances had been the mistress and ultimately the second wife of Robert, 5th earl of Sussex. The countess was an outspoken supporter of Parliament during the summer of 1642, although the disorder which followed the outbreak of war made her more cautious.
