After completing his formal education, in June 1620, the 22-year-old Twysden was knighted and sent on a tour of the Continent for three years. Returned for Winchelsea on the Finch interest in 1625, he left no trace on the records of the first Caroline Parliament. Re-elected in 1626, this time with his future father-in-law, he was appointed to five committees, among them the committees for legalizing payments to muster-masters (28 Mar.) and for mitigating sentences of excommunication (2 May).
Twysden’s sale of Honichurch manor ended the family interest in the Cinque Ports. However, by the end of the 1630s he had become one of the leaders of his county, which he represented in the Short Parliament. Imprisoned for his share in the Kentish petition of 1642, his attempted neutrality in the Civil War could not save his estate, worth £2,000 p.a., from sequestration.
