Keighley hailed from the Yorkshire parish of Whixley. Although his father described himself in his will as a yeoman, he was probably descended from a minor gentry family seated 15 miles away at Newall, Otley, Yorkshire.
As the principal link between Salisbury and his tenants, Keighley naturally assisted in mediating the earl’s electoral patronage, for example circulating the names of his nominees as Hertfordshire knights of the shire in 1625 and 1626.
Keighley made his will on 29 Jan. 1634, describing himself as a resident of St. Martin-in-the-Fields, though he requested burial near his wife and only child in St. Clement Danes church. He bequeathed £10 to the poor of that parish, similarly remembering the indigent of Green Hammerton, while his property in Middlesex, Hertfordshire and Yorkshire was left to his sister and nephews. By a codicil of 9 Feb. he also provided funeral clothing for his colleagues at Salisbury House on the Strand. As his joint executor he named his old friend Sir Thomas Brett.
